1. A Prospective Research to Assess the Association of type 2 Mellitus Diabetes with HbA1c, Lipid Profile, and CRP
Ramchandra Kumar, Jainendra Kumar, Raghvendra Kumar Singh
Aim: The aim of this study to determine the relation between HbA1c, Lipid profile and CRP in individuals with type 2 diabetes mellitus. Methods: This prospective observational study was carried out in the Department of General Medicine Nalanda Medical College and Hospital, Patna, Bihar, India .The patients above 28 years with fasting venous blood glucose value equal or more than 100 mg/dl and postprandial glucose >140 mg/dl were include in this study. FBS and PPBS, CRP (immunoturbidimetric method), and HbA1C (ion exchange chromatography using HPLC) lipid profile samples were drawn at entry and at subsequent follow-up with a minimum gap of 3-6 months. Results: Total cholesterol was compared to CRP. Number of patients with total cholesterol   <100 was 5, 100-200 were 35 between 200-300 were 22 with mean CRP of 1.78, 0.81, 2.87. There was a significant positive correlation between CRP and total cholesterol (p<0.05). LDL cholesterol was compared with CRP. Patients with LDL cholesterol <60 were 12, between 60-80 were 26, between 80-100 were 15, between 100-120 were 24, between 120-140 was 1,  >140 were 12 with mean CRP levels of 1.85, 0.84, 1.82, 0.75, 1.34, 2.29. There was no significant correlation between CRP and LDL cholesterol (p>0.05). HDL cholesterol was compared with CRP. Patients with HDL cholesterol between  0-20 were 3,  between  20-40  were  43, between 40-60  were  41  and  HDL  cholesterol  >60  were  3 with mean CRP levels of 2.14, 1.41, 1.22, 1.16, respectively. There was a negative correlation between HDL cholesterol and CRP triglyceride levels were compared with CRP. Patients with triglyceride levels between 100-200 were 45, between 200-300 were 30, between 300-400 were 8, between 400-500 was 3 and with levels >500 were 4 with mean CRP levels of 0.71, 0.84, 1.84, 2.45, 2.45, respectively. There was significant positive correlation between CRP and triglyceride levels (p<0.05). Conclusion: The CRP is an additional marker of better Glycaemic control and also correlates with the dyslipidaemia profile seen in type 2 diabetes mellitus. Keywords: C-reactive protein, Glycemic control, Hemoglobin A1C, Type 2 diabetes mellitus.