International Journal of

Toxicological and Pharmacological Research

e-ISSN: 0975 5160

p-ISSN: 2820-2651

Peer Review Journal

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1. Curcumin: A Chemopreventive Agent in Pre-Malignant Leisions
Manmohan Singhal, Yashwant, Amit Nayak, Vinayaditya Singh, Ashiah Singh Parihar
In spite of tremendous development in the field of allopathy during 20thcentury over 60 % of all pharmaceuticals are plant based .Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Traditionally known for its anti-inflammatory effects, Curcuma longa has a long history of therapeutic use in the Ayurvedic and Chinese systems of medicine. Curcumin exerts proimmune activity in several autoimmune disorders including Alzheimer’s disease, multiple sclerosis, cardiovascular disease, diabetes, allergy, asthma, inflammatory bowel disease, rheumatoid arthritis, renal ischemia, psoriasis, and scleroderma. Curcumin can also apparently modulate the activation of natural killer (NK) cells. Curcumin plays an important role in the immunomodulation of normal but also transformed T cells. Present study is a review on a description of its pharmacological action studied earlier & in recent year.

2. Progress in Gene Therapy : A Review
Deepshikha Pande Katare, Vidhu Aeri.
Currently used therapeutic systems are undergoing major changes, in the 21 st century. Gene therapy is likely to become an important therapeutic option in treatment of inherited diseases. Broadly, defined, the concept of gene therapy involves transfer of genetic material into a cell, tissue or whole organ, with the objective of curing a disease or improving the clinical status of the patient. Gene therapy carries the excitement of a cure-all for a host of diseases, the controversy surrounding the modulation of human genes, and the promise of a type of medical treatment most of us could not imagine as possible just a few years back. With its potential to eliminate and prevent hereditary diseases such as cystic fibrosis and hemophilia and its use as a possible cure for heart diseases, AIDS and cancer, gene therapy is a potential medical miracle. A key factor in e success of gene therapy is the development of delivery systems that are capable of efficient gene transfer to a variety of tissues without causing any associated pathogenic effects. Vectors based upon many different viral systems, including retroviruses, lent viruses, adenoviruses and adeno-associated viruses; currently offer the best choice for efficient gene delivery. This review outlines the major approaches used for gene delivery, the recent developments in this field of medicine.

3. Antidiabetic Activity of Leaves of Indiofera Tinctoria Linn (Fabaceae)
Verma S.M, Suresh K.B., Verma Amit
The methanolic extract of dried leaves of Indigofera tinctoria Linn showed significant decrease in blood glucose level of rabbits as estimated by Folin-Wu Method. In this experiment, alloxan is used as diabetes inducing agent.

4. Pharmacological Evaluation of S.trifoliatus Fruit Extract of the Plant S.trifoliatus in Ehrlich Ascites Carcinoma Tumor Bearing Mice
D. Pradhan, P.K. Panda, G. Tripathy
Evaluation of fruit of the plant S.trifoliatus in ehrlich ascites carcinoma (eac) tumor bearing mice was established. S.trifoliatus fruit extract extract 100 mg/kg, 200mg/kg body weight dose significantly reduced ascitic fluid volume. 300 mg/kg, 400 mg/kg reduced the percentage of viable ascitic cells to 47 and 48% respectively in the treated groups as compared to 93% in the EAC control. 500mg/kg increase the life span of the EAC treated mice by 112% and 100% respectively. All the doses of leaf extracts of the plant S.trifoliatus increased RBC count and hemoglobin content and decreased WBC count to near normal values, in EAC bearing mice. S.trifoliatus extract extracts marginally altered SGOT, SGPT values and significantly increased alkaline phosphatase. In creased urea and creatinine content in blood have been observed in 100 mg and 200 mg/Kg body wt dose. The Results of the present study clearly demonstrates the tumor inhibitory activity of the plant extracts against transplantable murine tumor cell line. The mechanism by which these compounds mediate is antitumor effect is still to be elucidated.


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