Cardio-ankle vascular index (CAVI) was used as the parameter of arterial stiffness. We aim to demonstrate the association of CAVI with the risk factors for cardiovascular disease (CVD) event. Total of 177 participants were randomly recruited and underwent anthropometric and CAVI measurement. Fasting blood samples were collected for all biochemical markers determination. Participants were classified into 2 groups based on CAVI measurement. Age, BP, mean arterial pressure, TC, TG, LDL-C, hs-CRP, insulin, HOMA-IR were significantly higher and BMI, HDL-C levels were significantly lower in participants with CAVI>0.9 (arterial stiffness). CAVI was correlated with Age, BMI, MAP, TC, HDL-C and hs-CRP (p<0.05). Multiple forward stepwise linear regression analyses of the significant variables showed that the independent predictors of arterial stiffness were Age (b=0.348, R²=0.306, p<0.001), hs-CRP (b=0.120, R² =0.407, p<0.001), BMI (b=-0.283, R²=0.445, p<0.001), HDL-C (b=-0.250, R²=0.480, p<0.001), TC (b=0.156, R²=0.504, p<0.001) and MAP (b=0.148, R² =0.522, p<0.001). CAVI was associated with CVD risk factors and could be used to assess arterial stiffness and to evaluate as a risk factor in asymptomatic patients.