International Journal of

Toxicological and Pharmacological Research

e-ISSN: 0975 5160

p-ISSN: 2820-2651

Peer Review Journal

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1. Review on Traditional Uses, Photochemistry and Medicinal Properties of Jatropha gossypiifolia L.
S. S. Sarangdevot, Bhumika Dadheech
Abstract
Jatropha gossypiifolia L. (Euphorbiaceae), widely known as “bellyache bush,” is a medicinal plant largely used throughout Africa and America. Several human and veterinary uses in traditional medicine are described for different parts and preparations based on this plant. However, critical reviews discussing emphatically its medicinal value are missing. This review aims to provide an up-to-date overview of the traditional uses, as well as the phytochemistry, pharmacology, and toxicity data of J. gossypiifolia species, in view of discussing its medicinal value and potential application in complementary and alternative medicine. Pharmacological studies have demonstrated significant action of different extracts and/or isolated compounds as antidiabetic, antimicrobial, anti-inflammatory, antidiarrheal, antihypertensive, and anticancer agents, among others, supporting some of its popular uses. No clinical trial has been detected to date. Further studies are necessary to assay important folk uses, as well as to find new bioactive molecules with pharmacological relevance based on the popular claims. Toxicological studies associated with phytochemical analysis are important to understand the eventual toxic effects that could reduce its medicinal value. The present review provides insights for future research aiming for both ethnopharmacological validation of its popular use and its exploration as a new source of herbal drugs and/or bioactive natural products.

2. Pre formulation Study of Ozenoxacin: An Analytical and Physicochemical Evaluation
Deepika, Rajendra Pal Singh Rathore
Abstract
Preformulation studies are a crucial phase in the development of any pharmaceutical dosage form, providing essential data about the physicochemical properties of a drug substance. This study focuses on the preformulation analysis of Ozenoxacin, a non-fluorinated quinolone antibiotic used for the topical treatment of impetigo. Various tests, including organoleptic evaluation, UV-visible spectroscopy, FTIR analysis, solubility profiling, and partition coefficient determination, were conducted to assess the drug’s compatibility, stability, and behavior in different environments. The results offer valuable insights for developing an optimized and effective formulation of Ozenoxacin.

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