In pharmaceutical development, the advancement of taste-masking techniques is pivotal in enhancing patient compliance, particularly among pediatric and geriatric populations. The goal is to develop palatable dosage forms while masking the inherent bitterness of active pharmaceutical ingredients (APIs). This study investigates the formulation and evaluation of a drug-resin complex for Temafloxacin, a bitter fluoroquinolone antibiotic, utilizing modern ion-exchange resin technology. Complexation efficacy, drug loading, and in vitro drug release behavior were analyzed to determine the suitability of Amberlite IRP 64 as a taste-masking resin. This approach aligns with current trends in patient-centric drug design and targeted oral delivery systems.